A new paper in Nature is reporting that “Altogether, in a [Saccharomyces] genome containing only 6,000 open reading frames (ORFs), we detected over 1.88 million unique transcript isoforms (TIFs) (or 776,874 supported by at least two sequencing reads…).” They detected 26 major TIFs (mTIFs) and 48 TIFs in total per open reading frame, and “estimate a maximum of 100 mTIFs (or 500 TIFs) per gene.”
And you thought yeast was simple?