140 pseudogenes found expressed in humans
|May 29, 2014||Posted by News under 'Junk DNA', News|
A draft map of the human proteome
Extract “In our data set, we identified more than 200 peptides that are encoded by 140 pseudogenes. These 140 pseudogenes originate from 110 parental genes. To derive this unambiguous set, we filtered out several peptides for which sequence change could be explained by SNPs reported for corresponding genes in dbSNP. When we looked at the tissue distribution of the translated pseudogenes, we observed that roughly half of the pseudogenes were translated in a cell/tissue-restricted manner whereas a small minority was expressed globally (Fig. 5a), a
pattern similar to that described for pseudogene transcripts30, 31. For instance, VDAC1P7 was found to be translated globally (22 of 30 cells/tissues analysed) whereas MAGEB6P1 was detected only in adult testes although its parental gene, EIF4B, is widely expressed (Fig. 5a). Extended Data Fig. 5c shows two peptides that map to MAGEB6P1, a pseudogene, along with an alignment of the identified peptides with the corresponding peptides in the parental gene. It should be noted that there is still a small chance that some SNPs are not represented in our analysis because we did not analyse the genomes of these individuals. However, this is unlikely to affect our results greatly because it has been estimated that approximately 98% SNPs with 1% frequency have been detected from the 1000 Genomes Project32.”
Talk about The Myth of Junk DNA.
See also: Junk DNA defender doesn’t do politeness.
Anyoe remember ENCODE? Not much junk DNA? Still not much.
What? Darwin’s followers did not use junk DNA as an argument for their position? Indeed, Christian Darwinists were hollering fer Jesus on the basis of junk DNA not too long ago too. Sorry, but it’s true.
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