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	<title>Comments on: Tuning Knobs and Other Features of the Genome</title>
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	<description>Serving The Intelligent Design Community</description>
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		<title>By: Collin DuCrÃƒÂ¢ne</title>
		<link>http://www.uncommondescent.com/intelligent-design/tuning-knobs-and-other-features-of-the-genome/comment-page-1/#comment-42670</link>
		<dc:creator>Collin DuCrÃƒÂ¢ne</dc:creator>
		<pubDate>Fri, 09 Jun 2006 21:16:02 +0000</pubDate>
		<guid isPermaLink="false">http://www.uncommondescent.com/index.php/archives/1188#comment-42670</guid>
		<description>Michaels7

&quot;agreed, spiritual Ã¢â‚¬Å“unbeliefÃ¢â‚¬Â is reversible and so to belief. If it were not so, then the seeds would all fall on good ground or pavement&quot;

Belief is not an intellectual excerise, requiring a constant effort of will. To know your saviour is to accept your salvation. This is a permanent condition, requiring zero effort to maintain.

Evolution rejects salvation, making it impossible to know your saviour. You cannot have it both ways. Let me draw you a picture:

          Creator     Creation
IE          NO          NO
ID          NO          YES  
Salvation   YES         YES

Any questions?</description>
		<content:encoded><![CDATA[<p>Michaels7</p>
<p>&#8220;agreed, spiritual Ã¢â‚¬Å“unbeliefÃ¢â‚¬Â is reversible and so to belief. If it were not so, then the seeds would all fall on good ground or pavement&#8221;</p>
<p>Belief is not an intellectual excerise, requiring a constant effort of will. To know your saviour is to accept your salvation. This is a permanent condition, requiring zero effort to maintain.</p>
<p>Evolution rejects salvation, making it impossible to know your saviour. You cannot have it both ways. Let me draw you a picture:</p>
<p>          Creator     Creation<br />
IE          NO          NO<br />
ID          NO          YES<br />
Salvation   YES         YES</p>
<p>Any questions?</p>
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	<item>
		<title>By: johnnyb</title>
		<link>http://www.uncommondescent.com/intelligent-design/tuning-knobs-and-other-features-of-the-genome/comment-page-1/#comment-42648</link>
		<dc:creator>johnnyb</dc:creator>
		<pubDate>Fri, 09 Jun 2006 18:46:30 +0000</pubDate>
		<guid isPermaLink="false">http://www.uncommondescent.com/index.php/archives/1188#comment-42648</guid>
		<description>&quot;No it doesnÃ¢â‚¬â„¢t. The processes are random. That which works persists. That which doesnÃ¢â‚¬â„¢t is eliminated. Binding sites are TA rich, meaning they are held together electrochemically less strongly than other regions. That grants them a number of interesting properties, one of which is that they mutate more readily.&quot;

Perhaps you should read the paper.  Did you also miss the tuning knobs?  Other examples of directed mutation:

http://jb.asm.org/cgi/content/full/182/11/2993
http://baraminology.blogspot.com/2005/12/evidence-for-todd-woods-altruistic.html
http://baraminology.blogspot.com/2006/02/more-on-directed-mutagenesis.html

Also, there is an element to &quot;randomness&quot; which both isn&#039;t random and is directed.  See my comments here:

http://baraminology.blogspot.com/2006/04/luck-favors-prepared-darling.html

Basically, if a mutation is partially specified, then a random search can be a fast way to it.</description>
		<content:encoded><![CDATA[<p>&#8220;No it doesnÃ¢â‚¬â„¢t. The processes are random. That which works persists. That which doesnÃ¢â‚¬â„¢t is eliminated. Binding sites are TA rich, meaning they are held together electrochemically less strongly than other regions. That grants them a number of interesting properties, one of which is that they mutate more readily.&#8221;</p>
<p>Perhaps you should read the paper.  Did you also miss the tuning knobs?  Other examples of directed mutation:</p>
<p><a href="http://jb.asm.org/cgi/content/full/182/11/2993" rel="nofollow">http://jb.asm.org/cgi/content/full/182/11/2993</a><br />
<a href="http://baraminology.blogspot.com/2005/12/evidence-for-todd-woods-altruistic.html" rel="nofollow">http://baraminology.blogspot.c.....istic.html</a><br />
<a href="http://baraminology.blogspot.com/2006/02/more-on-directed-mutagenesis.html" rel="nofollow">http://baraminology.blogspot.c.....nesis.html</a></p>
<p>Also, there is an element to &#8220;randomness&#8221; which both isn&#8217;t random and is directed.  See my comments here:</p>
<p><a href="http://baraminology.blogspot.com/2006/04/luck-favors-prepared-darling.html" rel="nofollow">http://baraminology.blogspot.c.....rling.html</a></p>
<p>Basically, if a mutation is partially specified, then a random search can be a fast way to it.</p>
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	<item>
		<title>By: Michaels7</title>
		<link>http://www.uncommondescent.com/intelligent-design/tuning-knobs-and-other-features-of-the-genome/comment-page-1/#comment-42437</link>
		<dc:creator>Michaels7</dc:creator>
		<pubDate>Thu, 08 Jun 2006 22:28:13 +0000</pubDate>
		<guid isPermaLink="false">http://www.uncommondescent.com/index.php/archives/1188#comment-42437</guid>
		<description>Mung,
Ã¢â‚¬Å“And here I thought the good news is that spiritual death (unbelief) is reversible. Perhaps you have it backwardsÃ¢â‚¬Â

Meant to respond earlier... agreed, spiritual &quot;unbelief&quot; is reversible and so to belief. If it were not so, then the seeds would all fall on good ground or pavement. Judgement of Spiritual Death however is final - referred to as the &quot;2nd death&quot; of which those who did not believe are blotted out from the Book of Life.

Physical death as recorded is reversible. But, once past, it is the passing of an old vessel where a seed was deposited and thru ultimate grace born anew in spiritual form(a higher form)  even by those who believe without seeing.

Collin, evolution worships the creature. True, ID does not state who the designer is, but that is a secular scientific principle that must be met for scholarship in this world. But if I were to make a tent and sell it like Paul and refuse to sell it to those who do not believe, of what profit is it to the House of the Lord? The message is not in ID itself and never was, but in individual testimony and always has been. The casting of the net was a mere realization of trust once the fish were caught. ID cast a large net, a 153 fish does not include all possible fish. Many creationist detest this part of ID. However the body of Christ is made of many parts. Should we do away with one to please the other? Who is to say how the Lord will call his sheep and thru whom will they be called? Each have gifts and are called by the will of the Father even at his timing and his ways, not ours. Is heroin a call? Not by us, but thru Him, all things are possible.  Maybe I misunderstood your post, but ID was never my reason to believe. If anyone places their faith on such thin ice(creature design no matter how wonderfully created), they&#039;ll fall thru.

Dave, I even heard some bulldogs were made in his likeness ;-)</description>
		<content:encoded><![CDATA[<p>Mung,<br />
Ã¢â‚¬Å“And here I thought the good news is that spiritual death (unbelief) is reversible. Perhaps you have it backwardsÃ¢â‚¬Â</p>
<p>Meant to respond earlier&#8230; agreed, spiritual &#8220;unbelief&#8221; is reversible and so to belief. If it were not so, then the seeds would all fall on good ground or pavement. Judgement of Spiritual Death however is final &#8211; referred to as the &#8220;2nd death&#8221; of which those who did not believe are blotted out from the Book of Life.</p>
<p>Physical death as recorded is reversible. But, once past, it is the passing of an old vessel where a seed was deposited and thru ultimate grace born anew in spiritual form(a higher form)  even by those who believe without seeing.</p>
<p>Collin, evolution worships the creature. True, ID does not state who the designer is, but that is a secular scientific principle that must be met for scholarship in this world. But if I were to make a tent and sell it like Paul and refuse to sell it to those who do not believe, of what profit is it to the House of the Lord? The message is not in ID itself and never was, but in individual testimony and always has been. The casting of the net was a mere realization of trust once the fish were caught. ID cast a large net, a 153 fish does not include all possible fish. Many creationist detest this part of ID. However the body of Christ is made of many parts. Should we do away with one to please the other? Who is to say how the Lord will call his sheep and thru whom will they be called? Each have gifts and are called by the will of the Father even at his timing and his ways, not ours. Is heroin a call? Not by us, but thru Him, all things are possible.  Maybe I misunderstood your post, but ID was never my reason to believe. If anyone places their faith on such thin ice(creature design no matter how wonderfully created), they&#8217;ll fall thru.</p>
<p>Dave, I even heard some bulldogs were made in his likeness <img src='http://www.uncommondescent.com/wp-includes/images/smilies/icon_wink.gif' alt=';-)' class='wp-smiley' /> </p>
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		<title>By: Collin DuCrÃƒÂ¢ne</title>
		<link>http://www.uncommondescent.com/intelligent-design/tuning-knobs-and-other-features-of-the-genome/comment-page-1/#comment-42420</link>
		<dc:creator>Collin DuCrÃƒÂ¢ne</dc:creator>
		<pubDate>Thu, 08 Jun 2006 20:18:00 +0000</pubDate>
		<guid isPermaLink="false">http://www.uncommondescent.com/index.php/archives/1188#comment-42420</guid>
		<description>ds,

The notion of ministering to genetic engineers is an excellent idea.

Thanks</description>
		<content:encoded><![CDATA[<p>ds,</p>
<p>The notion of ministering to genetic engineers is an excellent idea.</p>
<p>Thanks</p>
]]></content:encoded>
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	<item>
		<title>By: mevolution</title>
		<link>http://www.uncommondescent.com/intelligent-design/tuning-knobs-and-other-features-of-the-genome/comment-page-1/#comment-42419</link>
		<dc:creator>mevolution</dc:creator>
		<pubDate>Thu, 08 Jun 2006 20:17:27 +0000</pubDate>
		<guid isPermaLink="false">http://www.uncommondescent.com/index.php/archives/1188#comment-42419</guid>
		<description>First of all...
&quot;Mutation tends to occur at binding sites rather than structural sites, allowing a protein to diversify in a useful way (note to readers Ã¢â‚¬â€ this means the cell must contain intelligence of some sort about which sites are binding sites and which sites are structural sites)&quot;
--No it doesn&#039;t. The processes are random. That which works persists. That which doesn&#039;t is eliminated. Binding sites are TA rich, meaning they are held together electrochemically less strongly than other regions. That grants them a number of interesting properties, one of which is that they mutate more readily.

Secondly...
That Introns mutate at a faster rate is true. that they are under less selection pressure is also true. That has nothing whatsoever to do with Entropy. Geeze. Those regions don&#039;t code for specific amino acids, so the order of nucleotides in them is less significant. If they change it matters less. So, they change more. And, it&#039;s important to note that it is not the case that mutations occur more frequently in those areas. Mutations occur at steady rates. The mutation rate, in this case, applies to the rate of survivial in the species of those mutations. When a mutation causes a deleterious effect, it is rarely around long enough for anyone to know about it or count it up.</description>
		<content:encoded><![CDATA[<p>First of all&#8230;<br />
&#8220;Mutation tends to occur at binding sites rather than structural sites, allowing a protein to diversify in a useful way (note to readers Ã¢â‚¬â€ this means the cell must contain intelligence of some sort about which sites are binding sites and which sites are structural sites)&#8221;<br />
&#8211;No it doesn&#8217;t. The processes are random. That which works persists. That which doesn&#8217;t is eliminated. Binding sites are TA rich, meaning they are held together electrochemically less strongly than other regions. That grants them a number of interesting properties, one of which is that they mutate more readily.</p>
<p>Secondly&#8230;<br />
That Introns mutate at a faster rate is true. that they are under less selection pressure is also true. That has nothing whatsoever to do with Entropy. Geeze. Those regions don&#8217;t code for specific amino acids, so the order of nucleotides in them is less significant. If they change it matters less. So, they change more. And, it&#8217;s important to note that it is not the case that mutations occur more frequently in those areas. Mutations occur at steady rates. The mutation rate, in this case, applies to the rate of survivial in the species of those mutations. When a mutation causes a deleterious effect, it is rarely around long enough for anyone to know about it or count it up.</p>
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		<title>By: Collin DuCrÃƒÂ¢ne</title>
		<link>http://www.uncommondescent.com/intelligent-design/tuning-knobs-and-other-features-of-the-genome/comment-page-1/#comment-42410</link>
		<dc:creator>Collin DuCrÃƒÂ¢ne</dc:creator>
		<pubDate>Thu, 08 Jun 2006 17:53:45 +0000</pubDate>
		<guid isPermaLink="false">http://www.uncommondescent.com/index.php/archives/1188#comment-42410</guid>
		<description>&lt;p&gt;Mung,&lt;/p&gt;
&lt;p&gt;&quot;And here I thought the good news is that spiritual death (unbelief) is reversible. Perhaps you have it backwards&quot;&lt;/p&gt;
&lt;p&gt;The only backwards thing around here is a doctrine that encourages belief in Creation, but at the same time steps back from knowledge the Creator. That is simply an altar to an unknown god.&lt;/p&gt;
&lt;p&gt;The spiritual danger here is that ID could easily become the religion of genetic designers who worship themselves and their creations, discouraging belief in the true Creator.&lt;/p&gt;
&lt;p&gt;Scriptures are replete with warnings about this, but I am not here to do anybody&#039;s extremely late homework.
&lt;/p&gt;

&lt;b&gt;Doesn&#039;t scripture inform genetic engineers that they were created in God&#039;s likeness? -ds &lt;/b&gt;
</description>
		<content:encoded><![CDATA[<p>Mung,</p>
<p>&#8220;And here I thought the good news is that spiritual death (unbelief) is reversible. Perhaps you have it backwards&#8221;</p>
<p>The only backwards thing around here is a doctrine that encourages belief in Creation, but at the same time steps back from knowledge the Creator. That is simply an altar to an unknown god.</p>
<p>The spiritual danger here is that ID could easily become the religion of genetic designers who worship themselves and their creations, discouraging belief in the true Creator.</p>
<p>Scriptures are replete with warnings about this, but I am not here to do anybody&#8217;s extremely late homework.
</p>
<p><b>Doesn&#8217;t scripture inform genetic engineers that they were created in God&#8217;s likeness? -ds </b></p>
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		<title>By: johnnyb</title>
		<link>http://www.uncommondescent.com/intelligent-design/tuning-knobs-and-other-features-of-the-genome/comment-page-1/#comment-42258</link>
		<dc:creator>johnnyb</dc:creator>
		<pubDate>Wed, 07 Jun 2006 17:26:48 +0000</pubDate>
		<guid isPermaLink="false">http://www.uncommondescent.com/index.php/archives/1188#comment-42258</guid>
		<description>Thanks for the tip, but I&#039;m very sure my name is already in every spam engine known to man.  I&#039;d rather just make it easy for everyone else.

Anyway, the article should be updated, with an updated link and references at the bottom.  Why science paper sites can&#039;t simply put you on a linkable URL is beyond me.  Pubmed seems to do it just fine.</description>
		<content:encoded><![CDATA[<p>Thanks for the tip, but I&#8217;m very sure my name is already in every spam engine known to man.  I&#8217;d rather just make it easy for everyone else.</p>
<p>Anyway, the article should be updated, with an updated link and references at the bottom.  Why science paper sites can&#8217;t simply put you on a linkable URL is beyond me.  Pubmed seems to do it just fine.</p>
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		<title>By: Mung</title>
		<link>http://www.uncommondescent.com/intelligent-design/tuning-knobs-and-other-features-of-the-genome/comment-page-1/#comment-42256</link>
		<dc:creator>Mung</dc:creator>
		<pubDate>Wed, 07 Jun 2006 17:01:34 +0000</pubDate>
		<guid isPermaLink="false">http://www.uncommondescent.com/index.php/archives/1188#comment-42256</guid>
		<description>&lt;blockquote&gt;Physical death is reversible, but spiritual death (unbelief) is not.&lt;/blockquote&gt;

And here I thought the good news is that spiritual death (unbelief) is reversible. Perhaps you have it backwards. :)</description>
		<content:encoded><![CDATA[<blockquote><p>Physical death is reversible, but spiritual death (unbelief) is not.</p></blockquote>
<p>And here I thought the good news is that spiritual death (unbelief) is reversible. Perhaps you have it backwards. <img src='http://www.uncommondescent.com/wp-includes/images/smilies/icon_smile.gif' alt=':)' class='wp-smiley' /> </p>
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		<title>By: apollo230</title>
		<link>http://www.uncommondescent.com/intelligent-design/tuning-knobs-and-other-features-of-the-genome/comment-page-1/#comment-42243</link>
		<dc:creator>apollo230</dc:creator>
		<pubDate>Wed, 07 Jun 2006 12:24:15 +0000</pubDate>
		<guid isPermaLink="false">http://www.uncommondescent.com/index.php/archives/1188#comment-42243</guid>
		<description>Johnny, regarding post #10, you may want to re-instate your e-mail as &quot;nospam@eskimo.com (replace &quot;nospam&quot; with &quot;johnnyb&quot;)&quot;.

This way, spammers who troll the internet for e-mails will not be able to log your e-mail and bombard your butt with their crap.

See the top page fineprint of Dr. Dembski&#039;s website www.designinference.com that deals with permissions-he uses this trick!

Best regards,

apollo230</description>
		<content:encoded><![CDATA[<p>Johnny, regarding post #10, you may want to re-instate your e-mail as &#8220;nospam@eskimo.com (replace &#8220;nospam&#8221; with &#8220;johnnyb&#8221;)&#8221;.</p>
<p>This way, spammers who troll the internet for e-mails will not be able to log your e-mail and bombard your butt with their crap.</p>
<p>See the top page fineprint of Dr. Dembski&#8217;s website <a href="http://www.designinference.com" rel="nofollow">http://www.designinference.com</a> that deals with permissions-he uses this trick!</p>
<p>Best regards,</p>
<p>apollo230</p>
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		<title>By: apollo230</title>
		<link>http://www.uncommondescent.com/intelligent-design/tuning-knobs-and-other-features-of-the-genome/comment-page-1/#comment-42242</link>
		<dc:creator>apollo230</dc:creator>
		<pubDate>Wed, 07 Jun 2006 12:19:15 +0000</pubDate>
		<guid isPermaLink="false">http://www.uncommondescent.com/index.php/archives/1188#comment-42242</guid>
		<description>Ditto that, Bob OH!

Johnny, could you PLEASE provide a citation for said paper, because I encountered an error as well, and searching on Wiley&#039;s website for keywords &quot;mutation is modulated&quot; produced no matches.

Many thanks!!</description>
		<content:encoded><![CDATA[<p>Ditto that, Bob OH!</p>
<p>Johnny, could you PLEASE provide a citation for said paper, because I encountered an error as well, and searching on Wiley&#8217;s website for keywords &#8220;mutation is modulated&#8221; produced no matches.</p>
<p>Many thanks!!</p>
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