Uncommon Descent Serving The Intelligent Design Community

Reality: The Wall You Smack Into When You’re Wrong

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I’ve been in trial the last couple of weeks, and I am just now coming up for air.  I see the debate has continued in my absence.  Alas, yet another confirmation (as if another were needed) that I am not indispensible.  Thank you to all of our posters, commenters and lurkers, who continue to make this site one of the most robust stops on the internet vis-à-vis the intelligent design debate.

 We live in a post-modern world, and the defense position at trial last week brought that dreary fact forcefully to mind. 

Without going into detail, the trial was about a contract my clients (the plaintiffs) signed in 1996.  The defendant received the benefits of his bargain and was content for 11 years.  Then, when the contract turned to my clients’ benefit in 2007, the defendant refused to pay.  Instead, he hired one of the largest law firms in the world (over 600 lawyers) to get him out of the contract, and these last several months his team of lawyers and paralegals (six strong at last count) have submitted literally hundreds of documents to the court in a feverish effort to convince the judge that – though the defendant said nothing for 11 years – the contract was unenforceable from the beginning. 

Well, that is not entirely accurate.  I should say this is the position on which the defendant finally settled after various other theories failed.  At first he claimed the contract was valid, but my clients’ calculations were wrong, and they owed him money.  When that didn’t work he claimed the entire transaction was a sham, and he knew it from the beginning.  When it came to light he had certified the transaction to the IRS in 1997, his position changed yet again.  Now, his position was that he thought the transaction was valid in the beginning, but after he reviewed the documents in connection with this case he learned he had been hoodwinked.  The transaction was always a sham, but he just hadn’t known it all these years. 

 In golf a “mulligan” is the friendly practice of letting a player get a “do over” if his tee shot goes awry.  I suppose the defendant’s lawyers thought I was going to give them a mulligan and not mention at trial the varied and inconsistent positions they had taken.  But over a million dollars was at stake, so I decided I would pass on the mulligan, and when I had the defendant on the stand the cross went something like this:

 Q.  So if I understand what you’re saying, you didn’t know there was any irregularity with the transaction when you certified it to the IRS in 1996.

 A.  That’s right.

 Q.  In fact, you’re telling me that you never knew there was the slightest problem with this transaction until you reviewed the documents produced in connection with this case.

 A.  That’s right.  I never knew.

 Q.  I have just placed in front of you the sworn affidavit you signed last September.  Do you see paragraph three there?  It says, “I believe [here I raised my voice for effect], AND HAVE ALWAYS BELIEVED, the transaction was a sham.”  My question for you is this:  Just now you testified under oath that you NEVER believed there was anything wrong with the transaction.  But last September you swore out an affidavit in which you said you ALWAYS believed the transaction was a sham.  Help me out here.  How can both of those sworn statements be true at the same time?

 This, of course, is the trial lawyer’s dream scene.  He has caught the other party making statements that simply cannot be reconciled.  Both may be false (which is the case here), but there is no way both can be true.  Needless to say, my clients are happy today.

What does this have to do with post-modernism?  Just this.  Over the last few months I have often wondered if the other side really believed they would be able to get away with just “making it up.”  That question was answered by an incident that occurred on the second day of trial.  My paralegal was in the back of a crowded courthouse elevator.  One of the defendant’s lawyers and his paralegal were in the front, and apparently they did not know my paralegal was there, because she overheard them talking about the case.  The lawyer said, “They are presenting their version of reality and we are presenting a competing version of reality.  The case will come down to which version the judge finds compelling.” 

I never thought of myself as “presenting a version of reality.”  My goal was to just get the facts out about what happened, because I have always believed that if the judge knew what actually happened we would win.  It turns out that I am hopelessly old-fashioned about these things.  In our post-modern world there are no immutable “facts” for the judge to know.  There are only competing “narratives,” and she will make her decision based upon which narrative she finds most “compelling.”  And in developing his “narrative,” a lawyer need feel no obligation to quaint outdated notions such as “what actually happened.”  There is no “what actually happened,” because reality is not fixed, objective and immutable.  No, reality is malleable, subjective and constructed. 

I like to say that reality is the practical wall you smack into when you’re theory is wrong.  And thankfully trials are nothing if not practical endeavors.  No matter what a post-modernist might say about “all reality is subjectively constructed,” the truth of the matter is they all look both ways before crossing the street.  And it turns out that judges really do try to determine “what actually happened,” and another name for “presenting a competing version of reality” is “lying under oath,” which judges tend to frown on (as the defendant found out to his dismay).

I hope our opponents who post comments on this site will keep this story in mind.  I hope they think about it the next time they are tempted to write in response to one of the arguments an ID proponent makes, “Well, that’s your reality.  My reality is different.”  It is such a hackneyed, trite and dreary expression.  Worse, it is based on a self-evidently false premise, and, as the defendant found out, it will get you in trouble if you take it seriously.

Comments
Stephen at 249: I believe this subject got adequately sometime with you sometime in the past year or so, and I'm not going to get involved in that. Seeking natural explanations has been what science has been about for 500 years. I know what your position is, and I don't agree with you. But it is a fact - not prescribed by an elite but just a fact about how people behave - that science seeks natural explanations. A very small minority of ID advocates want to change this, but that is not a sufficient reason for saying that things have changed.Aleta
May 17, 2010
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Aleta: I have just a moment. Let me point out to you a sampler of the definitions of science that you will find in high quality dictionaries from before the imposition of materialist censorship under the name methodological naturalism:
science: a branch of knowledge conducted on objective principles involving the systematized observation of and experiment with phenomena, esp. concerned with the material and functions of the physical universe. [Concise Oxford, 1990] scientific method: principles and procedures for the systematic pursuit of knowledge [”the body of truth, information and principles acquired by mankind”] involving the recognition and formulation of a problem, the collection of data through observation and experiment, and the formulation and testing of hypotheses. [Webster's 7th Collegiate, 1965]
Now, let us compare the definitions put up by the different KS boards of education in 2001 and 2005 (noting that he 2007 version is essentially the same as the one from 2001):
2001 Definition: “Science is the human activity of seeking natural explanations of the world around us.” 2005 Definition: “Science is a systematic method of continuing investigation, that uses observation, hypothesis testing, measurement, experimentation, logical argument and theory building, to lead to more adequate explanations of natural phenomena.”
Do you see the ideological, worldview assumption-driven loading in the 2001 definition? And how the 2005 one seeks to reinstate a less loaded definition? And, as for the threat I spoke of, did you read the NAS-NSTA statement of 2005, which I excerpt in the crucial part:
. . . the members of the Kansas State Board of Education who produced Draft 2-d of the KSES have deleted text defining science as a search for natural explanations of observable phenomena, blurring the line between scientific and other ways of understanding. Emphasizing controversy in the theory of evolution -- when in fact all modern theories of science are continually tested and verified -- and distorting the definition of science are inconsistent with our Standards and a disservice to the students of Kansas. Regretfully, many of the statements made in the KSES related to the nature of science and evolution also violate the document’s mission and vision. Kansas students will not be well-prepared for the rigors of higher education or the demands of an increasingly complex and technologically-driven world if their science education is based on these standards. Instead, they will put the students of Kansas at a competitive disadvantage as they take their place in the world.
Let's see: students who learn a more traditional, less ideological definition of science will be ill equipped. To point out that say operational science with a direct check by direct observation is not on the same epistemic level of warrant as origins sciences that try to reconstruct an unobservable past is to distort the claim that all scientific theories are in effect as close to the truth as we can get, i.e. they are "verified""? And, such students will be ill prepared to go on to higher studies or sci-tech type desirable jobs? [Or, is it that with our refusal of the imprimatur, they will be blacklisted?] I think you need to take a second look overnight. GEM of TKI PS: Verified: "To prove the truth of by presentation of evidence or testimony; substantiate." [AmHDict, 1st meaning]kairosfocus
May 17, 2010
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Aleta,,, please tell me that conclusive evidence for evolution again I can't seem to remember it,,, fossil record,,,No,,, Genes,,, No,,,proteins,,,No,,,morphology,,,No,,, geographical distribution,,,no,, mutations,,,No,,, dang aleta can you help me?bornagain77
May 17, 2010
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aleta states: "Science standards for high school kids are meant to describe the mainstream view, which the Kansas standards certainly do." Mainstream view? (drumroll please) Happy Birthday, Mr. Darwin: According to the poll, Democrats (82%) and liberals (86%) are even more likely than Republicans (73%) and conservatives (72%) to support the academic freedom of teachers and students to discuss the “strengths and weaknesses of evolution.” The poll also shows a dramatic 9-point increase over 2006 in the percentage of likely voters who agree that “Biology teachers should teach Darwin’s theory of evolution, but also the scientific evidence against it.” Support for that position has jumped to 78%, up from 69% in 2006. The percentage of likely voters who favor teaching only the evidence for evolution suffered a corresponding decline of 7 points, from 21% in 2006 to just over 14% this year. http://www.evolutionnews.org/2009%20Zogby%20Poll%20Findings%20Report%20Final.pdfbornagain77
May 17, 2010
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Aleta states: "but the ID minority changed it, and then the NAS wrote a letter supporting the majority position.' Eugenie Scott states: "Science is not a democratic process"bornagain77
May 17, 2010
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---Aleta: "Science standards for high school kids are meant to describe the mainstream view, which the Kansas standards certainly do. Public school science standards should not be the battleground for these philosophical and cultural battles." I just explained to you that no one held the view that science must limit itself to the study of natural causes until the 1980's. Those who introduced that intrusive rule started the war, not those who challenged it. Have you no respect for historical facts?StephenB
May 17, 2010
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Note: my response to kairosfocus that I quoted to Stephen doesn't exactly fit, as kf accused non-materialists of kow-towing to the "materialist elite", and Stephen accuses them of being naive. But it's the same thing: not being willing to accept the genuineness of other people's differing view, ascribing some defective factor (cowardice, naivete, confusion or whatever) in order to bolster one's conviction that one alone is right. It's still indefensible. I think most of us agree that we should treat others as we would like to be treated, and I don't think you folks would accept it if others told you that, despite your beliefs to the contrary, you believed what you did out of cowardice, naivete, or confusion. I for one am glad to argue that you are wrong, but I wouldn't stoop, I don't think, to trying to tell you that you are kidding yourself about why you believe what you do.Aleta
May 17, 2010
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kf: "Then look at what the US NAS tried to threaten school kids in Kansas with." No, the NAS didn't "threaten" anyone. The Kansas science committee included the exact same definition of science that had been in the previous standards (the one about seeking natural explanations), but the ID minority changed it, and then the NAS wrote a letter supporting the majority position. That's all. Science standards for high school kids are meant to describe the mainstream view, which the Kansas standards certainly do. Public school science standards should not be the battleground for these philosophical and cultural battles. kf: "Go haunt a few Darwinist sites [including those led by Darwinist academics], and see the shrill, even rabid ideologised tone, and how they so often view and treat those who differ with them with contempt and hostility:" How you can you possible write this after yourself writing innumerable "shrill, even rabid ideologised" posts on this site, a site whose members often "view and treat those who differ with them with contempt and hostility." This is the pot calling the kettle black. kf: "PS: And, I think it is fair comment to note that above, and elsewhere including in the always linked, I have dealt with the issues surrounding Design on the merits, in responsible details. I do not appreciate being misrepresented on that as you did just above." I do not see where I wrote anything "above" that implied that you didn't at times discuss the issue of Design on its merits, despite that fact that you wrap it all up in an excessive amount of rhetoric ("oil-soaked strawman" et al). I don't think you are right, but that doesn't mean that I don't think you don't discuss details. Therefore, I'm not sure what you are referring to when you say I misrepresented you. And Stephen writes, "That a number of non-materialsits have naively signed on to the materialist agenda does not mean that it is not a materialist agenda." I will repeat what I said to kairosfocus:
This is an insult to the beliefs of millions of people – how can you be so arrogant as to ascribe these motives to people rather than to accept what they themselves say about the issue? Actually, I know the answer to that question: to accept that people with different religious and philosophical viewpoints do not see the issues about science and ID that you do underscores the fact that ID is a religious and philosophical viewpoint that doesn’t really add anything to the science itself. Rather than enter into a positive discussion with the world about the value of your belief system in contrast with other belief systems, you feel like you have to hijack science in order to add credibility to your view. It would be far better, and more honest, in my opinion, to accept that these are religious and philosophical issues, and engage the public on that basis.
Aleta
May 17, 2010
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Yes, that's the one.above
May 17, 2010
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Above, Like this video? Gkairosfocus
May 17, 2010
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I never understood what the big deal with ID was. Why so many materialists hate it so much... What stephen said above reminded me of that and the inevitable answer I got to my question from eugenie scott in one of the interviews. I am paraphrasing here but her position was: Freedom of speech (1st amendment) is a great thing but it has no place in science. But isn't science supposed to built on the freedom of rational inquiry? Is this what science has been reduced to? *Anyone interested in the interview, you can see an excerpt of it in the icons of evolution.above
May 17, 2010
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Stephen, Thanks. Gkairosfocus
May 17, 2010
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PS: And, I think it is fair comment to note that above, and elsewhere including in the always linked, I have dealt with the issues surrounding Design on the merits, in responsible details. I do not appreciate being misrepresented on that as you did just above.kairosfocus
May 17, 2010
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---aleta: "there are many, many scientists, and educated people in general, who are not materialists and who accept science as the search for natural explanations." That a number of non-materialsits have naively signed on to the materialist agenda does not mean that it is not a materialist agenda. ---"Those clamoring to do otherwise have not shown how searching for non-natural causes is possible – rather, those clamoring to do otherwise have been shown to be primarily interested in introducing philosophical and religious speculations into science, which basically is asking us to go back about 500 years." The burden if proof falls on those who arrogate unto themselves the right to define science for themselves and everyone else. In fact, no one has the right to set down arbitrary rules for the purpose of ruling out inconvenience evidence or suppressing controversial theories. Only the scientist knows which problems and questions he/she is trying to address and, therefore, only the scientist can choose the appropriate methods. ---"Most people would rather stick with what has worked." What has always worked is freedom. What never works is tyranny. Almost all of the great scientists of the past were design thinkers and were free to develop their own paradigms, many of which included specific references to God. They were, as they put it, "thinking God's thoughts after him. Methodological naturalism is an arbitrary rule established in the 1980's for the sole purpose of discrediting intelligent design. These are the facts.StephenB
May 17, 2010
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Aleta: Please, go check the facts, as already linked. The issue is not emotions but facts, facts with very, very serious and sobering import. Read what was done to Richard Sternberg, not for supporting ID [which he did not] but for being an honest journal editor. (He won't tell you about being accused of being a thief and a fraud etc by co-workers, but the congressional staff report and its Appendix A will fill in some truly ugly details. Have a look at the attempts to discredit and blams the victim and attack the messenger in response to the substance of the investigations. When you have done this, look hard in a mirror, and ask yourself if this is a pattern of ideologised behaviour you want to associate yourself with.) Then look at what the US NAS tried to threaten school kids in Kansas with. Then, think through the implications of the ideologisation of Science Lewontin -- remember, a member of the said same scientific elite, testified to. And which the NAS underscored. Go haunt a few Darwinist sites [including those led by Darwinist academics], and see the shrill, even rabid ideologised tone, and how they so often view and treat those who differ with them with contempt and hostility: "ignorant, stupid, insane or wicked" is just he beginning. Especially observe how they routinely distract from issues on the merits, distort the views of those who differ with them [cf the Weak Argument Correctives on this] and soak such strawmen with ad homiem attacks, igniting them to cloud, confuse and poison the atmosphere. Then, having paused to absorb the implications of the self-referential incoherence of evolutionary materialism and its inescapable is-ought gap driven amorality [which I have seen in action up close and personal], come back here and tell me that I am over-reading the implications of the pattern of behaviour and the dangers it portends. And show me why you draw that conclusion, on what evidence. GEM of TKIkairosfocus
May 17, 2010
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KF, I am sorry about the political things you have experienced, but I think you are quite wrong to draw a strong parallel between such experiences and the nature of science and those who practice it. Sentences like "In science and science education, we now have a dominant, ruthlessly amoral a priori materialist elite that is threatening kids in school for studying science outside their materialist imprimatur" are hyperbolic exaggerations, and do injustice to lots of good people. Thank you, however, for clarifying the connection between politics and science that you think is true, because it does help me understand a bit where the strength of your emotions about these topics come from.Aleta
May 17, 2010
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Aleta: I am sorry, but this will have to be painful reading. I am black, with a name that reminds me of the man who was hanged in my native land, in reminder of just how dangerous it is to be right when the power brokers are wrong. I come from a colonialised country and went to a university that was at the time marxist -- largely in rage over the unquestionably outrageous sins of the colonialists. Marxism got a lot of things wrong, and I was one of their strongest, most outspoken critics on campus [not least, on the campus they became a small scale mirror image of what they objected to in our history and ongoing experience -- it is harder to get the plantation mindset out of you than to get off of the plantation!]; but their point on dominant elites and how they operate and how people are intimidated or indoctrinated and adapt to survive and in some cases thrive is too close for comfort. (Why not read this parable by Plato, from such a third world viewpoint.) In science and science education, we now have a dominant, ruthlessly amoral a priori materialist elite that is threatening kids in school for studying science outside their materialist imprimatur. Frankly, for learning the truth about the difference between observationally supportable operational and origins sciences that are trying to reconstruct a remote unobservable past, and for understanding that science should be open minded and humble about what it knows or can know, to what degree of confidence, in pursuing the truth about our world. (And, some years ago, we had it out at length in UD threads with some of those who were playing those power games while imagining that all was hunky dory. So, we know from experience, eyewitnesses and documents not hearsay.) For decades, they have manipulated evidence, history, policy debates and more. [For instance, when I learned the truth about former US Secretary of State William Jennings Bryan, I was by degrees astonished then outraged: this man has been slandered and lied on, in situations where he was far more nearly right than those who have so viciously caricatured him, e.g.in the wretched Inherit The Wind stereotypes.] Scientists who do not line up with the elite agenda get stomped on, overtly and covertly. (You should see the slanderous blame the victim working over that some have been through, sometime, like a certain Richard Sternberg.) Under those circumstances, sustained for decades, people are unconsciously pulled to accommodate their views to the views of the dominant elites. Worse if he education and media systems are manipulated. in extreme cases the Stockholm Syndrome kicks in, and people begin to identify with their oppressors. I do not dispute the sincerity of people, and their attempts to accommodate their views to what they were led to think is fact, is as near to truth as makes no difference. Just, something was not adding up. And there is a magisterium in lab coats running things, many of whom were themselves raised and educated to think the same. Many of whom have major vested interests in the system as it now is. Just think: how many are willing to sacrifice not just the comforts of an easy life but career, reputation, how history will look back on you, and maybe more, in pursuit of something that the learned power brokers and august bodies assure us is heresy without warrant? And no, I am not talking about Europe circa 1517, but the state of origins science and science education today. That is how ideologies too often dominate civilisations and institutions. It is also how the infamous march of folly gets us to collectively head over the cliff. Tie after time after time. So, please take time to seriously look at the matter on the merits instead of playing the shoot the messenger if you don't like the message card. Pardon if this is a painful read, but I do not take easily to rhetorical bullets headed my way like that. G'day GEM of TKIkairosfocus
May 17, 2010
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Aleta @236, Well said. Science should be concerned with naturally describing the natural world we live in.Toronto
May 17, 2010
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Actually, I know the answer to that question ("how can you be so arrogant as to ascribe these motives to people rather than to accept what they themselves say about the issue?"): to accept that people with different religious and philosophical viewpoints do not see the issues about science and ID that you do underscores the fact that ID is a religious and philosophical viewpoint that doesn't really add anything to the science itself. Rather than enter into a positive discussion with the world about the value of your belief system in contrast with other belief systems, you feel like you have to hijack science in order to add credibility to your view. It would be far better, and more honest, in my opinion, to accept that these are religious and philosophical issues, and engage the public on that basis.Aleta
May 17, 2010
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Kairosfocus writes, "I repeat ..." True. Kf also writes, "Non materialists who accept the attempt to censor the scientific investigation of origins in accord with materialistic presuppositions are trying to accommodate to the balances of power in the elite circles." This is an insult to the beliefs of millions of people - how can you be so arrogant as to ascribe these motives to people rather than to accept what they themselves say about the issue?Aleta
May 17, 2010
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Aleta that quote on insanity is real popular in AA: Definition of Insanity: Repeating the same thing over and over again while expecting different results. Tubthumping(i get knocked down) by Chumbawamba http://www.youtube.com/watch?v=kS-zK1S5Dwsbornagain77
May 17, 2010
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Ilion, almost as bad as forgetting what Mr Smith drummed into my head about the integral of a polynomial term, de4cades ago! [Aleta thanks for the correction] Gkairosfocus
May 17, 2010
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Aleta: Non materialists who accept the attempt to censor the scientific investigation of origins in accord with materialistic presuppositions are trying to accommodate to the balances of power in the elite circles [in a context of a long, growing and shameful list of the expelled]. I repeat, science at its best is an unfettered (but ethically and intellectually responsible) progressive pursuit of teh truth ablut our cosmos, based on evidence and analysis. When entire categories of possible explanation [intelligence working by art and leaving signs of intellfgence such as complex functional organisation and information) are a priori ruled out by imposing a rule on an ideology, that censorship corrupts science. Which is what Lewontin, in his own way, was talking about. GEM of TKIkairosfocus
May 17, 2010
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Aleta you state: "Most people would rather stick with what has worked." Though this statement is chuck full of hidden false assumptions, let's suffice it to say,,, Definition of Insanity: Repeating the same thing over and over again while expecting different results.bornagain77
May 17, 2010
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"PS: Pardon the format error on the close strike and the odd typo." Oh, man! That's even worse than my slip-up the other day. You did that just to make me feel better, didn't you? ;-)Ilion
May 17, 2010
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kj, there are many, many scientists, and educated people in general, who are not materialists and who accept science as the search for natural explanations. Those clamoring to do otherwise have not shown how searching for non-natural causes is possible - rather, those clamoring to do otherwise have been shown to be primarily interested in introducing philosophical and religious speculations into science, which basically is asking us to go back about 500 years. Most people would rather stick with what has worked.Aleta
May 17, 2010
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kairosfocus @227,
“There is scientific consensus that the capacity to synthesize nylonase most probably developed as a single-step mutation that survived because it improved the fitness of the bacteria possessing the mutation.”
So single-step evolution works. From this you conclude the following,
Thus, immediately, nylonase is irrelevant to the proposed issue of step by step producing a novel body plan embracing 10’s of millions of new bases and specifying a whole new body architecture; by cumulative small variations and natural selection.
that it doesn't.Toronto
May 17, 2010
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PPPS: Excerpt 10, fixed: ____________ 10] Mutations can cause loss of function which can be catastrophic for the organism but, occasionally, as in the case of the nylon-eating Flavobacterium it can add a new function, even if that it is at the expense of some other function. In fact, “Mutations can [overwhelmingly] cause loss of function which can be catastrophic for the organism." Further, no cases have been identified where such mutations produced say 500 bases worth of novel, functional bio-information. In fact, the studies on malaria show that two-to-three co-ordinated mutations is an effective practical upper limit for mutational innovations. (And the implication of this for mutations as the claimed source of bio-information and novel body plans is that we see how despite more reproductive events than all of the vertebrate line can have had, malaria has been unable to surmount so "simple" a barrier as the sickle cell trait causing mutation.) As for nylonase, this is a gross exaggeration. A first clue is this remark from the Wiki article: "There is scientific consensus that the capacity to synthesize nylonase most probably developed as a single-step mutation that survived because it improved the fitness of the bacteria possessing the mutation.” Thus, immediately, nylonase is irrelevant to the proposed issue of step by step producing a novel body plan embracing 10’s of millions of new bases and specifying a whole new body architecture; by cumulative small variations and natural selection. That is why, as long ago as 2005, Dembski here at UD remarked:
Miller fails to show that the construction/evolution of nylonase from its precursor actually requires CSI at all. As I develop the concept, CSI requires a certain threshold of complexity to be achieved (500 bits, as I argue in my book No Free Lunch). It’s not at all clear that this threshold is achieved here . . . . Nylonase appears to have arisen from a frame-shift in another protein. Even so, it seems to be special in certain ways. For example, the DNA sequence that got frame-shifted is a very repetitive sequence. Yet the number of bases repeated is not a multiple of 3 (in this case, 10 bases are probably the repeating unit). What this means is that the original protein consisted of repeats of these 10 bases . . .
10 bases in a repeating frame is a whole order of magnitude below the threshold for FSCI, and it has nothing to do with innovation of a body plan that has to be embryologically viable. This also shows up the strawman tactic resorted to by the sort of materialism advocates who argue . . .
that this research would seem to refute claims made by creationists and intelligent design proponents, specifically, the claim that random mutation and natural selection can never add new information to a genome [LIE: CSI implies a threshold, and 500 - 1,000 bits is a useful measure of where it kicks in], and the claim that the odds against a useful new protein such as an enzyme arising through a process of random mutation [LIE, 2: the issue raised by Hoyle was the ab initio origin of the cluster of enzymess required for life, not the odds against a frame shift mutation in already existing and functional bacteria] would be prohibitively high . . .
See the problem of materialist rhetoric of distraction, distortion and denigration that I and others have had to keep pointing out? _____________kairosfocus
May 17, 2010
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PPS: X Ray crystrallography study results on EII nylonase:
6-Aminohexanoate-dimer hydrolase (EII), responsible for the degradation of nylon-6 industry by-products, and its analogous enzyme (EII?) that has only ?0.5% of the specific activity toward the 6-aminohexanoate-linear dimer, are encoded on plasmid pOAD2 of Arthrobacter sp. (formerly Flavobacterium sp.) KI72. Here, we report the three-dimensional structure of Hyb-24 (a hybrid between the EII and EII? proteins; EII?-level activity) by x-ray crystallography at 1.8 Å resolution and refined to an R-factor and R-free of 18.5 and 20.3%, respectively. The fold adopted by the 392-amino acid polypeptide generated a two-domain structure that is similar to the folds of the penicillin-recognizing family of serine-reactive hydrolases, especially to those of d-alanyl-d-alanine-carboxypeptidase from Streptomyces and carboxylesterase from Burkholderia. Enzyme assay using purified enzymes revealed that EII and Hyb-24 possess hydrolytic activity for carboxyl esters with short acyl chains but no detectable activity for d-alanyl-d-alanine. In addition, on the basis of the spatial location and role of amino acid residues constituting the active sites of the nylon oligomer hydrolase, carboxylesterase, d-alanyl-d-alanine-peptidase, and ?-lactamases, we conclude that the nylon oligomer hydrolase utilizes nucleophilic Ser112 as a common active site both for nylon oligomer-hydrolytic and esterolytic activities. However, it requires at least two additional amino acid residues (Asp181 and Asn266) specific for nylon oligomer-hydrolytic activity. Here, we propose that amino acid replacements in the catalytic cleft of a preexisting esterase with the ?-lactamase fold resulted in the evolution of the nylon oligomer hydrolase.
In short, relatively minor change to an existing enzyme, with resulting more generic activity (and I gather reduced activity on the original target).kairosfocus
May 17, 2010
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PS: Pardon the format error on the close strike and the odd typo.kairosfocus
May 17, 2010
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