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A Dilemma for Haldane

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Another day; another bad day for Darwinism. This is so true that I rarely post here anymore. Why bother? Darwinism is beat up everyday by its adherents doing experiments.

Here’s another one.

The team investigated the validity of Haldane’s predictions for the probability of fixation of a beneficial allele. They used C. elegans because it reproduces asexually, thus ensuring “genetic identity” from one generation to the next.

While validating Haldane’s predictions for the initial introduction of both deleterious and beneficial alleles to a population, they found this:

If its [i.e., the allele’s] frequency was higher than 5% (when more than five different individuals in a population of 100 individuals), the allele was perceived as deleterious and it started to be eliminated by natural selection. But when the frequency was less than 5%, the allele was beneficial. The result of these complex dynamics is that genetic diversity could be maintained indefinitely, without one allele or the other ever being fixed in the population.

IIRC, several years ago, in a study involving bacteria, it was found that when a bacterial population utilizing one type of sugar was place in the environment of a different type sugar, then the population switched over to the new sugar type; however, the ‘allele’ for the original sugar was never COMPLETELY eliminated from the population. Only WGA could determine this.

What these two examples suggest is that the ‘genome’ has the ability to monitor the level of use of any particular ‘allele’, and that depending on its current ‘use’, the ‘allele’ that would be ‘deleterious’ for the current environment is held at some minimal level so that should the environment change in the future, the needed ‘allele’ [then ‘beneficial’] would be ready at hand. [Which makes sense given how improbable it is to generate an allele from scratch]

To my mind, this calls the very idea of Natural Selection into question. We already know—Dawkin’s tells us this—that Natural Selection is no more than the “Grim Reaper.” Thus, NS is no more than the elimination of “unfit” alleles through “death.” But, in this scenario—backed up by the two experiments I’m speaking of—it is the population itself which determines what is ‘deleterious’, and hence eliminated via “death,” and which is ‘beneficial.’ In this case, it is the genome—very likely communicating with itself via individual genomes—that is making the “SELECTION;” NOT ‘nature.’

This is potentially devastating to Darwinian thought. But, don’t worry, you can be sure that our Darwinian ‘true-believers’ will invent some new ‘epicycle’ to explain—in their minds only—this deathblow to population genetics.

Comments
And, yet, supposedly, SELECTION treats it as ‘more fit’ or ‘less fit’. How in the world can “selection,’ which is, of course, operative when it is determined that the GFP line is ‘more fit’, turn around and now decide it is ‘less fit’? Because genes and other nematodes are part of the environment. The environment changed, so did the fitness function for each of these lines. But, of course, you don’t know at all. And, so, SCIENCE STOPS. “Oh, this is just FDS. End of story. Case closed.And, yet, supposedly, SELECTION treats it as ‘more fit’ or ‘less fit’. How in the world can “selection,’ which is, of course, operative when it is determined that the GFP line is ‘more fit’, turn around and now decide it is ‘less fit’? I described a simple model - a density-dependent process. As for stopping science - about three comments I go I said I hope those guys are sequencing their lines, because it would exciting to see how the the frequency-dependence they demonstrate arises. So, I'd like them to keep doing science. I'm very happy to leave it here, but I can't agree it's at all obvious that this pattern can't arise from frequency-dependent selectionwd400
September 16, 2013
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I really have no idea why you think using a term used for 'one' allele can now just magically be applied to the entire genome. It's as if having a term to describe the phenomena is all you need. It gives you a sense of knowing what's going on. But, of course, you don't know at all. And, so, SCIENCE STOPS. "Oh, this is just FDS." End of story. Case closed. That the GFP lineage is 'more fit' than the 'wild type' is a FACT. And, yet, supposedly, SELECTION treats it as 'more fit' or 'less fit'. How in the world can "selection,' which is, of course, operative when it is determined that the GFP line is 'more fit', turn around and now decide it is 'less fit'? This REQUIRES AN EXPLANATION; NOT A NAME. I have argued more than once that EVENTUALLY Darwinism will be put to the one side; but in the meantime so much valuable time is wasted. Why? Because Darwinism is completely misguided and has scientists asking the wrong questions. But in this case, it has scientists asking NO questions. What a pity. Don't bother responding. We're now arguing over the obvious. You choose to deny it. I don't. Let's leave it at that.PaV
September 16, 2013
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I really have no idea what you insist all calling this something other that what it is (and what the authors call it, for that matter). Yes the GFP is a marker for many different alleles at which the two isogenic lines will differ. I don't see how that changes anything but for the fact we dont' know which alleles are giving rise to the pattern of frequency dependance.wd400
September 16, 2013
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Apprently the article is open access. Here's the link. wd400:f I had to guess, and given the set up of the experiment, I’d say the alleles under selection are involved in metabolism. With one allele letting nematodes make use of scarce resource. One that allele is common the benefit dissipates as the resource is competed for (i.e. selection is density-dependent) so the allele’s fitness is determined in part by how many nematodes carry it. It turns out that they used inbred lines as 'surrogates' for an allele. The reason this is NOT FDS is due to the fact that a particular 'allele' is NOT being selected for, or kept in balance. Instead, it is the organism itself, the lineage. The GFP (introgrossed Green Flourescent Protein line) is beneficial below 5% and above 93%. The only 'stable' equilibrium point (between lineages!) is at 5%.
When between 5 and 93%, however, selection will be against the GFP allele. In other words, there was frequency-dependent selection among the two inbred lines.
(N.B. The GFP 'allele' is no more than a 'proxy' for the lineage.) This is completely in line with what I wrote @33: Here we have a self-fertilizing (or asexually reproducing) population; so they're NOT communicating via their the sharing of genes 'directly,' so, it shouldn't be surprising that they do so 'indirectly.'] If this is true, then, as I stated in the OP, this means that “selection” is dependent on the genome, and not the other way around; although here, we might say ‘selection’ is dependent on the ‘collective’ genome. Let's remember that the GFP is 'more fit' than the other, 'wildtype', lineage. This then means that SELECTION somehow determines that the GFP are 'more fit' up to 5% of the population, then 'less fit' from 6% to 92%, and then, at 93% decides that it is 'more fit' again. Remember, SELECTION is none other than either 'death,' or 'sterility.' They say that the effects they see are the same at the L1 'larval stage' as it is for adults. This means that 'death' is likely not involved; i.e., 'selection' is not making a distinction from the time the worm was at the larval stage up to the time of its being an adult. And, presumably as an adult, being 'more fit' the GFP's should have an advantage; but we don't see this. Thus, it is most likely that something happens before the L1 stage, including some kind of limitation in the number of offspring being produced; i,.e., a loss of fertility (outright 'sterility' was not reported). The authors say: "It is possible that underlying frequency-dependent selection are differences in the reproductive behaviour of the two inbred lines, as they seem to differ in embryo laying and embryo retention rates, as well as in successfully propagating themselves in our speci?c culture protocol . . .." From this vantage point, what I said @33 also applies: Third, the only reasonable and logical explanation is that the population—not the individual—is responsible for deciding whether or not the new allele should be treated as ‘beneficial’ or ‘deleterious.’ Fourth, this is only possible if there is some way in which the individuals in the population are somehow ‘signaling’ to one another. [We now know that horizontal gene transfer is not limited only to bacteria. Indeed, this "signaling" could easily take the form of some specific protein directly affecting fertility. It could be the case that the 'wild type' population (less fit) produces some 'signaling' protein with the ability to diminish the number of offspring produced, but which, in the case of the 'wild type's, is counteracted by another protein, or by some regulatory network that negates its effect. This is NOT FDS. And it points to chemical signaling by the population as a whole. IOW, 'selection' is but a phantom here---as it very well could be in many other places as well. There is, we know, the whole new world of 'epigenetics' that is opening up. NS, and Darwinism, are unlikely survivors. But that doesn't require math-ability of the behalf of nematodes of a mystical thing called “Selection”. Would you have us believe that a lineage that is known to be 'more fit' than another lineage, when introduced at a frequency between 6% and 92%, will be treated by 'selection' as 'less fit.' On what basis? Remember, they're reproducing asexually via hemaprodites. The lineages are not changing; they're simply competing. And yet we're to believe that 'selection' can decide: "Oh, it's too high; let me eliminate some. Oh. its frequency is not high enough. Let me eliminate some." What's your explanation?PaV
September 16, 2013
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Though it does tell you something about Ridley's approach to biology, I don't think that's a particularly difference is it Mung? A genotype's fitness is determined by it phenotype, after all.wd400
September 15, 2013
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Wikipedia:
Frequency-dependent selection is the term given to an evolutionary process where the fitness of a phenotype is dependent on its frequency relative to other phenotypes in a given population.
Ridley:
Frequency-dependent selection occurs when the fitness of a genotype depends on its frequency.
lolMung
September 15, 2013
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nd, yet, ‘selection’ acts as though ‘allele A’ is ‘deleterious’, or LESS FIT, solely on the basis of whether or not it is being introduced into the larger population at, or above, a certain percentage (frequency) Yeah - it's fitness is dependent on it's frequency, which is called frequency dependent selection. A balanced polymorphism like this presumable arises when the alleles under selection compete at some level. If I had to guess, and given the set up of the experiment, I'd say the alleles under selection are involved in metabolism. With one allele letting nematodes make use of scarce resource. One that allele is common the benefit dissipates as the resource is competed for (i.e. selection is density-dependent) so the allele's fitness is determined in part by how many nematodes carry it. As I say, the specifics are a guess. But that doesn't require math-ability of the behalf of nematodes of a mystical thing called "Selection". I hope the researchers are sequencing there strains, as it will be exciting to see how is underlying the processes they describe.wd400
September 15, 2013
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wd400: The reason I used the term Frequency Dependant Selection (FDS) was so that you might go off and read a little about this well researched phenomenon. Well, doesn't this remark of yours imply that I HAVEN'T read about FDS? Well, of course, it does. But I have read about it. Kimura explains it quite nicely in his The Neutral Theory. But, again, this ISN'T FDS. This should be obvious. Why you have a need to pigeon-hole this experiment into FDS is puzzling. That you are incorrect in your assessment is made clear by asking this simple question: "If this were no more than FDS, then why are the authors quoted as saying: 'But our results show that further empirical work and more theoretical models are required to accurately predict the fate of that allele over long time spans'?" Look at what I posted @34 in response to Elizabeth. Your implicit assumption in this matter is that 'selection' acts differently in different environments, or in different circumstances, and, that, given these 'different environments' either 'allele A' or 'allele B' is preferred, and that 'selection' simple acts accordingly. However, as I pointed out to Elizabeth, we're dealing here with TWO populations that are then mixed together in various proportions. INDEPENDENTLY of the 'mixing,' 'allele A', let's say, has been shown to be MORE FIT than 'allele B' in some given environment. Presumably (I don't have full access to the original article), when the populations are 'mixed,' this SAME environment is the one being used. And, yet, 'selection' acts as though 'allele A' is 'deleterious', or LESS FIT, solely on the basis of whether or not it is being introduced into the larger population at, or above, a certain percentage (frequency). The very simple question then is this: "How in the world does 'selection' KNOW what the percentage (frequency) of 'allele A' IS [in the first place]---let alone, how MUCH it should be.?" Could you answer these questions for me?PaV
September 15, 2013
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So how is Elizabeth equivocating you ask? It's simple. In one breath she speaks of diversity within a population, and then in the next speaks of diversity across taxa. Her initial "point" had to do with populations and the differences between individual members of the population, a "point" which she still has not defended. http://en.wikipedia.org/wiki/Genetic_variationMung
September 15, 2013
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PaV, The reason I used the term Frequency Dependant Selection (FDS) was so that you might go off and read a little about this well researched phenomenon. If you do that, you'll find the idea that "NS" (or, in fact, nematodes) have to be math-proficient for FDS to work is just not right.wd400
September 14, 2013
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wd400 [@5]:
Dear me, frequency dependant selection is not a new discovery.
PaV, Case closed, apparently. “It’s simple, PaV, we’ve known about this for a long time….” This is a very common evolutionist tactic. If something problematic is discovered, they will refer back to some unusual study done years ago and say "See? We already knew about this!" As if it is some kind of counter-argument. I guess they figure it provides the illusion that the problem has been dealt with... or since the problem's been around so long and evolutionism is still getting published, then it must not be that bad.lifepsy
September 14, 2013
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Then there is this fruit-fly selection study from 2010 http://www.nature.com/nature/journal/v467/n7315/abs/nature09352.html
Genome-wide analysis of a long-term evolution experiment with Drosophila Burke et al. 2010 Experimental evolution systems allow the genomic study of adaptation, and so far this has been done primarily in asexual systems with small genomes, such as bacteria and yeast. Here we present whole-genome resequencing data from Drosophila melanogaster populations that have experienced over 600 generations of laboratory selection for accelerated development. Flies in these selected populations develop from egg to adult ~20% faster than flies of ancestral control populations, and have evolved a number of other correlated phenotypes.... Signatures of selection are qualitatively different than what has been observed in asexual species; in our sexual populations, adaptation is not associated with ‘classic’ sweeps whereby newly arising, unconditionally advantageous mutations become fixed... We conclude that, at least for life history characters such as development time, unconditionally advantageous alleles rarely arise, are associated with small net fitness gains or cannot fix because selection coefficients change over time.
In other words, reaching reproductive age 20% faster was not translated as enough of a gain in reproductive fitness for the trait to become fixated in a population. (classic sweep) Yet you guys believe a deer-like creature will be on its way to becoming a whale in comparable time-frames... so ridiculous.lifepsy
September 14, 2013
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Elizabeth,
This is exactly why crude models of population genetics don’t work – the allele frequency itself alters the environment that determines the selection coefficient of the allele.
Elizabeth, can you kindly link to the "working" pop-gen experiments? (bonus: experiments that don't involve maximum selection coefficients, where lack of trait leads to certain death)lifepsy
September 14, 2013
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Elizabeth Liddle: [@6}
PaV, absolutely nothing in that paper poses any problem for evolutionary theory at all! It’s a very elegant paper, and it demonstrates empirically a very important evolutionary principle.
But, Elizabeth, the authors themselves say: "But our results show that further empirical work and more theoretical models are required to accurately predict the fate of that allele over long time spans". So, "nothing in that paper poses problems for evolutionary theory," and, yet, the authors tell us that "more theoretical models are needed"? Seems like they think something's wrong.
Evolutionary theory is about reproductive success in the current environment. That environment includes other populations in the habitat, as well as your own.
From the article: "Taking advantage of C. elegans' characteristics, Ivo Chelo and Judit Nédli used two lines of C. elegans to establish competition assays and see which individuals could survive and reproduce better." IOW, they took TWO populations. One population was MORE FIT than the other. When they introduced a high number of "more fit" alleles into the "less fit" population, they were treated as if they were "less fit." Please explain this to me.PaV
September 14, 2013
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wd400 [@5]:
Dear me, frequency dependant selection is not a new discovery.
Case closed, apparently. "It's simple, PaV, we've known about this for a long time...." Really. This ISN'T "frequency dependent selection." "Alleles" are being INTRODUCED into an otherwise 'identical' line of organisms. If they introduce 5, or less, of the variant type worm into a population of 100 worms, then the 'allele' is 'beneficial.' If more than 5, then it's 'deleterious.' Tell me, is NS math proficient? This isn't "competition" between alleles---as is frequency dependent selection---this is, rather, a determination of "how" the newly introduced 'alleles' will be treated. When you react to something like this with the "we've known this all along" attitude, then how in the world will you ever get around to critically questioning the theory you embrace. Let's look at the implications involved here. First, the use of the terms 'beneficial' and 'deleterious' probably just mean that the "frequency" of the alleles are either 'increasing' or 'decreasing' within the population as the generations proceed. Second, if 'selection' is at the level of the 'individual', then how in the world can 'selection' decide whether to treat the new alleles as 'beneficial' or 'deleterious'? They're the same 'alleles' whether they represent 10 individuals among 100, or only 2 individuals among 100. That's why I asked if NS is math proficient. Third, the only reasonable and logical explanation is that the population---not the individual---is responsible for deciding whether or not the new allele should be treated as 'beneficial' or 'deleterious.' Fourth, this is only possible if there is some way in which the individuals in the population are somehow 'signaling' to one another. [We now know that horizontal gene transfer is not limited only to bacteria. Here we have a self-fertilizing (or asexually reproducing) population; so they're NOT communicating via their the sharing of genes 'directly,' so, it shouldn't be surprising that they do so 'indirectly.'] If this is true, then, as I stated in the OP, this means that "selection" is dependent on the genome, and not the other way around; although here, we might say 'selection' is dependent on the 'collective' genome. IDists are accused of "stopping science." And, yet, this absolute certainty in Darwinism stops you, wd400, from asking the appropriate questions; whereas, I move on to ponder the implications that might be involved. Elizabeth Liddle: this criticism might also apply to you. "To those who have ears, listen!" I've just pointed out what an enterprising young biologist might want to explore.PaV
September 14, 2013
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We’ll try, but with a readership of about 100, I view this blog as draft and trial areas for ideas to get free editorial and peer review.
You've gotta be kidding me. These are the foundations of a new science? Spelling errors are probably because everyone upgraded their Macs and the autocorrector is working overtime.sigaba
September 14, 2013
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Hey, guys! I want to raise an apparently minor concern about our presentation here on UD. Lately, in many of our columns, I’ve noticed atrocious spelling errors, sometimes even in the headlines. Here, for example, we have “dilemna” instead of “dilemma.” This isn’t just a fussy point about English. ID people are often classed as “creationists,” and “creationists” are often stereotyped (by reference to polls attempting to connect religious belief with fewer years of formal education, etc.) as less educated than the general population, as anti-education, anti-culture, etc. When an ID website features frequent spelling errors, this just confirms the stereotype. You don’t see many spelling errors in columns written by Dawkins, Coyne, Collins, Miller, etc.
We'll try, but with a readership of about 100, I view this blog as draft and trial areas for ideas to get free editorial and peer review. The commenters like yourself and others have provided editorial corrections, for which I am extremely grateful. I review what I write several times, but things slip through the cracks because I often misread what I've written. I sometimes don't find it until I come back 2 weeks later. Thank you for your corrections and all of your editorial improvements of what I've written. You've helped me present my ideas better. Thank you.scordova
September 14, 2013
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This is potentially devastating to Darwinian thought.
I doubt it. The type of behavior described in the paper is what I would have expected. I agree it is not strictly Darwinian, and it is partly because I expect this kind of behavior that I say I am not a Darwinist. But people at UD and biologists keep telling me that I really am a Darwinist, so the distinction can't be large. I expect this kind of behavior, because it is what would seem to be necessary for evolution to work well. And it seems to follow that Darwinian natural selection would itself adapt to the needs of evolution (or population survival) by adopting this not-strictly-Darwinian strategy. Your post asserts:
They used C. elegans because it reproduces asexually, thus ensuring “genetic identity” from one generation to the next.
That does not appear to be strictly correct. The authors write:
These tiny organisms primarily reproduce by self-fertilization, which assures that genetic identity is maintained.
Perhaps my terminology is off, but I see "asexual" as implying that only mitosis is used, while self-fertilization implies the use of meiosis. And it is meiosis that mixes things up enough to maintain some level of variation.Neil Rickert
September 14, 2013
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One way to think of this is to say it’s as if selection is trying to maintain a maximally fit population – if there were less of these new alleles they would be favoured so become more frequent. But if there were more of them they would be further selected against and become less frequent. In time they arrive the equilibrium frequency (+/- a bit of drift from generation to generation). These are acrually a really nice example of the sorts of models we often run with undergrad geneticists, but with actual animals. Which is pretty cool.
I understand is the frequency variation of alleles. I do not see how these mechanism that seems to tend to keep homehostasis can be extrapolated to a mechanism that led to the increasing diversity of life forms.Chesterton
September 14, 2013
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At least you're not and don't want to be part of an IDist Movement or IDist 'Community,' timaeus, right? :P You're "pulling back" from UD, right timaeus? Oh, hang on, should they ('guys'-only!) use your Alabama-American English, timaeus, or be free to use British or Canadian English instead? C'mon IDists, git smurter kwickly, so that timaeus will finally be proud enough to join you! :)Gregory
September 14, 2013
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Hey, guys! I want to raise an apparently minor concern about our presentation here on UD. Lately, in many of our columns, I've noticed atrocious spelling errors, sometimes even in the headlines. Here, for example, we have "dilemna" instead of "dilemma." This isn't just a fussy point about English. ID people are often classed as "creationists," and "creationists" are often stereotyped (by reference to polls attempting to connect religious belief with fewer years of formal education, etc.) as less educated than the general population, as anti-education, anti-culture, etc. When an ID website features frequent spelling errors, this just confirms the stereotype. You don't see many spelling errors in columns written by Dawkins, Coyne, Collins, Miller, etc. If columns are originally typed up in a word processor, they can be spell-checked before copying and pasting to the UD author site. Of course, spell-checkers don't catch everything, so I recommend that writers also have good, large, thorough English dictionary of the traditional kind at hand. Also, if the writer has a wife, parent, brother or friend who is better at English (including not only spelling but grammar, usage, and punctuation), it wouldn't hurt to fly columns by that person before posting them. I realize, of course, that some apparent spelling errors can be just typos, and don't indicate ignorance of spelling. But even typos shouldn't find their way into titles or columns here; proofreading is in order. If the secular humanists and materialists all write polished stuff and we write sloppy stuff, it just confirms prejudices. Noncommitted readers may say: "If these ID guys don't know their English very well, maybe they aren't very educated, and maybe they don't know their science any better." As I say, it may seem like a small point, but we are in the persuasion business, and when you are trying to persuade people, they notice everything about you -- not just your arguments and your evidence, but your whole presentation. If you show up at a job interview with a gravy stain on your jacket and your tie on crooked, you may well lose the job even though you know more about the business than the person with the stain-free suit and the tie looking like James Bond's. This is something that can be cleaned up easily, with minimal care and attention. Can we work on it?Timaeus
September 14, 2013
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Not many people know this but John Scott Haldane (the father of neo-Darwinist J. B. S. Haldane) was a leading critic of genetic determinism/reductionism and he certainly would of rejected Dawkins concept of selfish genes and neo-Darwinism. See for example his book "Mechanism, Life and Personality. An Examination of the Mechanistic Theory of Life and Mind" (1913) which was a criticism of materialism and reductionism and supported a form of holistic organicism in biology. He believed the organism as fundamental to biology: "we perceive the organism as a self-regulating entity", "every effort to analyse it into components that can be reduced to a mechanical explanation violates this central experience". His views would be similar to Denis Noble, viewing the organism as a connected system or whole and not just reducing them to gene alone.TheisticEvolutionist
September 14, 2013
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You could do those things, Mung. Here's a place you could start: Diversity, disparity, and evolutionary rate estimation for unresolved Yule trees Disparity is one of the terms that goes into a diversity estimate.Elizabeth B Liddle
September 14, 2013
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Or I could try to discover what is meant by diversity and how it is measured. And I could try to discover what is meant by disparity and how it is measured. And I might discover that disparity is not a measure of diversity. And I might discover that you're equivocating over the term diversity. Probably better that you just clarify whatever point it is that you thing you're making.Mung
September 13, 2013
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I could, but you could just do a literature search, or even construct a model. Hint: feedback.Elizabeth B Liddle
September 13, 2013
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Elizabeth Liddle:
Lots of alleles never fix, especially in a large population. That’s how diversity is maintained.
Diversity is maintained by alleles which are never fixed, especially in large populations. The HOW is a bit vague. Care to say more?Mung
September 13, 2013
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Daniel K @16,
I applaud the ID advocates here for avoiding such self-destructive behavior. Convenient, isnt’t it?
Why yes, quite. And all the more, in fact, since it is a natural byproduct of being right.Brent
September 13, 2013
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But selection is not about chosing the best fit not keeping all? Yes. The most fit in the environment in any given generation. The environment includes the other genes present in the population, so, sometimes the fitness of an allele depends on its frequency in the population. One way to think of this is to say it's as if selection is trying to maintain a maximally fit population - if there were less of these new alleles they would be favoured so become more frequent. But if there were more of them they would be further selected against and become less frequent. In time they arrive the equilibrium frequency (+/- a bit of drift from generation to generation). These are acrually a really nice example of the sorts of models we often run with undergrad geneticists, but with actual animals. Which is pretty cool.wd400
September 13, 2013
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as to "It’s a major theme of Dawkins’ book The Selfish Gene from 1976." Unfortunately for those who would wish to cite 'The Selfish Gene' in support of neo-Darwinian evolution, all the major foundational presuppositions under-girding what Dawkins held to be true in his book 'The Selfish Gene' are now shown to be false: Modern Synthesis Of Neo-Darwinism Is False – Denis Nobel – video http://www.metacafe.com/w/10395212 ,, In the preceding video, Dr Nobel states that around 1900 there was the integration of Mendelian (discrete) inheritance with evolutionary theory, and about the same time Weismann established what was called the Weismann barrier, which is the idea that germ cells and their genetic materials are not in anyway influenced by the organism itself or by the environment. And then about 40 years later, circa 1940, a variety of people, Julian Huxley, R.A. Fisher, J.B.S. Haldane, and Sewell Wright, put things together to call it ‘The Modern Synthesis’. So what exactly is the ‘The Modern Synthesis’? It is sometimes called neo-Darwinism, and it was popularized in the book by Richard Dawkins, ‘The Selfish Gene’ in 1976. It’s main assumptions are, first of all, is that it is a gene centered view of natural selection. The process of evolution can therefore be characterized entirely by what is happening to the genome. It would be a process in which there would be accumulation of random mutations, followed by selection. (Now an important point to make here is that if that process is genuinely random, then there is nothing that physiology, or physiologists, can say about that process. That is a very important point.) The second aspect of neo-Darwinism was the impossibility of acquired characteristics (mis-called “Larmarckism”). And there is a very important distinction in Dawkins’ book ‘The Selfish Gene’ between the replicator, that is the genes, and the vehicle that carries the replicator, that is the organism or phenotype. And of course that idea was not only buttressed and supported by the Weissman barrier idea, but later on by the ‘Central Dogma’ of molecular biology. Then Dr. Nobel pauses to emphasize his point and states “All these rules have been broken!”. Professor Denis Noble is President of the International Union of Physiological Sciences.bornagain77
September 13, 2013
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OT: podcast: "Censorship Loses: New Scientific Volume Challenges Neo-Darwinism" http://intelligentdesign.podomatic.com/entry/2013-09-13T17_29_03-07_00bornagain77
September 13, 2013
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