Three dimensional chromosome arrangements can affect genetics
|March 2, 2012||Posted by News under 'Junk DNA', Genetics, News|
A Darwinist was bugging a friend to provide peer-reviewed literature about the three-dimensional arrangement of chromosomes (the c-nome), that affects genetics. That Darwinist favours a one-dimensional arrangement (surprise, surprise).
He needs to get out more. From Jonathan Wells’ The Myth of Junk DNA (p. 79):
Between cell divisions, chromosomes are not randomly distributed in the nucleus. Instead, they occupy distinct domains [79-82] that affect gene regulation‹in part, by bringing together specific regions of the chromosomes and facilitating interactions among them. [83-88] Different cell and tissue types in the same animal can have different three-dimensional patterns of chromosomes in their nuclei, which account for at least some differences in gene expression. [89-90]
 Stephen M. Stack, David B. Brown & William C. Dewey, ³Visualization of interphase chromosomes,² Journal of Cell Science 26 (1977): 281299. Freely accessible (2011) at http://jcs.biologists.org/cgi/reprint/26/1/281
 Jenny A. Croft, Joanna M. Bridger, Shelagh Boyle, Paul Perry, Peter Teague & Wendy A. Bickmore, ³Differences in the Localization and Morphology of Chromosomes in the Human Nucleus,² Journal of Cell Biology 145 (1999): 11191131. Freely accessible (2011) at http://jcb.rupress.org/content/145/6/1119.full.pdf+html
 Heiner Albiez, Marion Cremer, Cinzia Tiberi, Lorella Vecchio, Lothar Schermelleh, Sandra Dittrich, Katrin Küpper, Boris Joffe, Tobias Thormeyer, Johann von Hase, Siwei Yang, Karl Rohr, Heinrich Leonhardt, Irina Solovei, Christoph Cremer, Stanislav Fakan & Thomas Cremer, ³Chromatin domains and the interchromatin compartment form structurally defined and functionally interacting nuclear networks,² Chromosome Research 14 (2006): 707733.
 Thomas Cremer & Marion Cremer, ³Chromosome Territories,² Cold Spring Harbor Perspectives in Biology 2 (2010): a003889. Freely accessible (2011) at http://cshperspectives.cshlp.org/content/2/3/a003889.full.pdf+html
 Emanuela V. Volpi, Edith Chevret, Tania Jones, Radost Vatcheva, Jill Williamson, Stephan Beck, R. Duncan Campbell, Michelle Goldsworthy, Stephen H. Powis, Jiannis Ragoussis, John Trowsdale & Denise Sheer, ³Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome chromosome 6 and its response to interferon in interphase nuclei,² Journal of Cell Science 113 (2000): 15651576. Freely accessible (2011) at http://jcs.biologists.org/cgi/reprint/113/9/1565
 Li-Feng Zhang, Khanh D. Huynh & Jeannie T. Lee, ³Perinucleolar
targeting of the inactive X during S phase: evidence for a role in the maintenance of silencing,² Cell 129 (2007): 693706.
 Christian Lanctôt, Thierry Cheutin, Marion Cremer, Giacomo Cavalli & Thomas Cremer, ³Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions,² Nature Reviews Genetics 8 (2007): 104115.
 Boris Joffe, Heinrich Leonhardt & Irina Solovei, ³Differentiation and large scale spatial organization of the genome,² Current Opinion in Genetics and Development 20 (2010): 562569.
 M. R. Hübner & D. L. Spector, ³Chromatin dynamics,² Annual Review of Biophysics 39 (2010): 471489.
 Hideki Tanizawa, Osamu Iwasaki, Atsunari Tanaka, Joseph R. Capizzi, Priyankara Wickramasinghe, Mihee Lee, Zhiyan Fu & Ken-ichi Noma, ³Mapping
of long-range associations throughout the fission yeast genome reveals global genome organization linked to transcriptional regulation,² Nucleic Acids Research 38 (2010): 81648177. Freely accessible (2011) at http://nar.oxfordjournals.org/content/38/22/8164.long
 Luis A. Parada, Philip G. McQueen & Tom Misteli, ³Tissue-specific spatial organization of genomes,² Genome Biology 5:7 (2004): R44. Freely accessible (2011) at http://genomebiology.com/content/pdf/gb-2004-5-7-r44.pdf
 Tom Sexton, Heiko Schober, Peter Fraser & Susan M. Gasser, ³Gene regulation through nuclear organization,² Nature Structural & Molecular Biology 14 (2007): 10491055.