Open Mike: Cornell OBI Conference Chapter 7—Probability of Beneficial Mutation—Conclusion
|August 13, 2013||Posted by News under Cornell Conference, Genetics|
To facilitate discussion, we are publishing the abstracts and conclusions/summaries of the 24 papers from the Cornell Conference on the Origin of Biological Information here at Uncommon Descent, with cumulative links to previous papers at the bottom of each page.
Note: The hard cover version is now shipping.
The conclusion for Multiple Overlapping Genetic Codes Profoundly Reduce the Probability of Beneficial Mutation by George Montañez, Robert J. Marks II, Jorge Fernandez, John C. Sanford:
Our analysis confirms mathematically what would seem intuitively obvious — multiple overlapping codes within the genome must radically change our expectations regarding the rate of beneficial mutations. As the number of overlapping codes increases, the rate of potential beneficial mutation decreases exponentially, quickly approaching zero. Therefore the new evidence for ubiquitous overlapping codes in higher genomes strongly indicates that beneficial mutations should be extremely rare. This evidence combined with increasing evidence that biological systems are highly optimized, and evidence that only relatively high-impact beneficial mutations can be effectively amplified by natural selection, lead us to conclude that mutations which are both selectable and unambiguously beneficial must be vanishingly rare. This conclusion raises serious questions. How might such vanishingly rare beneficial mutations ever be sufficient for genome building? How might genetic degeneration ever be averted, given the continuous accumulation of low impact deleterious mutations?
See also: Origin of Biological Information conference: Its goals
Open Mike: Origin of Biological Information conference: Origin of life studies flatlined
Open Mike: Cornell OBI Conference— Can you answer these conundrums about information?
Open Mike: Cornell OBI Conference—Is a new definition of information needed for biology? (Chapter 2)
Open Mike: Cornell OBI Conference—New definition of information proposed: Universal Information (Chapter 2)
Open Mike: Cornell OBI Conference—Chapter Three, Dembski, Ewert, and Marks on the true cost of a successful search
Open Mike: Cornell OBI Conference—Chapter Three on the true cost of a successful search—Conservation of information
Open Mike: Cornell OBI Conference—Chapter Four: Pragmatic Information
Open Mike: Cornell OBI Conference—Chapter Four, Pragmatic information: Conclusion
Open Mike: Cornell OBI Conference Chapter Five Abstract
Open Mike: Cornell OBI Conference Chapter Five – Basener on limits of chaos – Conclusion
Open Mike: Cornell OBI Conference Chapter Six – Ewert et all on the Tierra evolution program – Abstract
Open Mike: Cornell OBI Conference Chapter Six – Ewert et all on the Tierra evolution program – Conclusion
Open Mike: Cornell OBI Conference Chapter 7—Probability of Beneficial Mutation— Abstract