“Evolution of genetic code” article illustrates fundamental problem
|February 4, 2017||Posted by News under Design inference, Evolution, Genetics, News|
There are currently three major theories on the origin and evolution of the genetic code: the stereochemical theory, the coevolution theory, and the error-minimization theory. The first two assume that the genetic code originated respectively from chemical affinities and from metabolic relationships between codons and amino acids.
The error-minimization theory maintains that in primitive systems the apparatus of protein synthesis was extremely prone to errors, and postulates that the genetic code evolved in order to minimize the deleterious effects of the translation errors. This article describes a fourth theory which starts from the hypothesis that the ancestral genetic code was ambiguous and proposes that its evolution took place with a mechanism that systematically reduced its ambiguity and eventually removed it altogether. This proposal is distinct from the stereochemical and the coevolution theories because they do not contemplate any ambiguity in the genetic code, and it is distinct from the error-minimization theory because ambiguity-reduction is fundamentally different from error-minimization. The concept of ambiguity-reduction has been repeatedly mentioned in the scientific literature, but so far it has remained only an abstract possibility because no model has been proposed for its mechanism. Such a model is described in the present article and may be the first step in a new approach to the study of the evolution of the genetic code. (paywall) – Evolution of the Genetic Code: The Ribosome-Oriented Model Barbieri, M. Biol Theory (2015) 10: 301. doi:10.1007/s13752-015-0225-z More.
The problem is: “This article describes a fourth theory which starts from the hypothesis that the ancestral genetic code was ambiguous and proposes that its evolution took place with a mechanism that systematically reduced its ambiguity and eventually removed it altogether.”
Systematic reduction of ambiguity is called design. Thanks for making it so clear. We had tried but we don’t have this guy’s gift for clear explanation.
See also: Large numbers of exceptions to the canonical genetic code
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