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Cellular mid-bodies (once thought rubbish) are the new junk DNA?

In “Obscure Organelle in Stem Cells and Cancer” (The Scientist , September 11, 2011) Kerry Grens reports,

Cellular structures known as midbodies, formed during cell division, appear to accumulate in stem cells and cancer cells, hinting at a potential function for these once-disregarded organelles.

Midbodies, once considered the rubbish of cell division, might have a function beyond their role in getting daughter cells to separate. Researchers show in today’s Nature Cell Biology that stem cells and cancer cells collect used midbodies, whereas differentiated cells digest the organelle through autophagy.

There must be some reason the cell doesn’t just get rid of them like all the rest.

“The midbody is now emerging as a signaling center or an organizer for things that may have to do with the stemness of cells,” said Andreas Ettinger, a postdoctoral researcher at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, who was not involved in this study.

Time-lapse of GFP-actin in a cell going through mitosis. You can see the contractile ring form, which ends up forming the mid-body:


See also: Junk DNA: The Darwin faithful know in their hearts that it’s still junk

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One Response to Cellular mid-bodies (once thought rubbish) are the new junk DNA?

  1. Towards the end of this video, animator has a cool animation on two chromosomes being separated::

    Astonishing Molecular Machines – Drew Berry – video
    http://www.metacafe.com/w/6861283/

    A few more notes:

    The Stages of Mitosis – hybrid animated video
    http://www.youtube.com/watch?v=VGV3fv-uZYI

    Getting a tighter grip on cell division – November 2010
    The molecular machinery that shepherds and literally pulls the chromosomes apart consists of paired microtubules radiating from opposite poles of the dividing cell and an enormous, but precise, molecular complex called a kinetochore.
    http://www.physorg.com/news/20.....ision.html

    Dividing Cells ‘Feel’ Their Way Out Of Warp
    “What we found is an exquisitely tuned mechanosensory system that keeps the cells shipshape so they can divide properly,” – Douglas N. Robinson, Ph.D.
    http://www.sciencedaily.com/re.....142402.htm

    600 Genes Involved in Fundamental Cell Division – Cornelius Hunter – July 2011
    Excerpt: The hundreds of genes are involved in an absolutely fundamental biological process is yet another example of evolution’s failure to explain biology.
    http://darwins-god.blogspot.co.....-cell.html

    Dna Molecular Biology Visualizations – Wrapping And DNA Replication – video
    http://www.youtube.com/watch?v=E8NHcQesYl8

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